Thursday 21 November
Auditorium 2
07:30 - 08:30
Registration
08:30 - 08:45
Welcome and introduction
Dr Guillermo Dighiero
(Uruguay)
[cv]
Dr Raúl Gabus
(Uruguay)
[cv]
Dr Thomas Kipps
(USA )
[cv]
Dr
Guillermo Dighiero
Uruguay
Curriculum Vitae:
URUGUAY
1960: Ingreso a la Facultad de Medicina. 1969: Graduación como médico. 1964: Practicante Interno del laboratorio Central del Hospital de Clínicas. 1968: Practicante Interno del Ministerio de Salud Pública. 1971: Asistente de la Clínica Semiológica de la Facultad de Medicina. 1975: Profesor Adjunto de la Clínica Semiológica de la Facultad de Medicina. 2004: Director Ejecutivo del Institut Pasteur de Montevideo.
FRANCIA
1975: Profesor Asociado de la Facultad de Medicina Paris VI. 1978: Docteur ès sciences. 1979: Ingreso al CNRS. 1984: Jefe de la Unidad de Inmuhematología e Inmunopatología del Instituto Pasteur. 1991: Director de Investigaciones de Primera Clase en el CNRS. 1996: Profesor del Instituto Pasteur. 1997: Director del Departamento de Fisiopatología del Instituto Pasteur. 1999: Presidente del Grupo Francés para el estudio de la Leucemia Linfoide Crónica
Curriculum Vitae:
Internal Medicine. Hematologist. President Organizing Committee - 5th LAG-CLL 2024, Uruguay.
Former Head of Department Hematology and BMT. Hospital Maciel. Montevideo. Uruguay.
Founding member of the Latin American Group on CLL.
Founding member in clinical and biology investigation in CLL. Hospital Maciel-Institut Pasteur. Montevideo.
Member of the IMC/ASH 2014.2022.
Founding member and Training Coordinator (LAVTP) in BMT for the Latin America Training Program /ASH 2014-2024
Curriculum Vitae:
Is Distinguished Professor of Medicine, Evelyn and Edwin Tasch Chair in Cancer Research, Director of the Center for Novel Therapeutics, and Co-Director of the Hematologic Malignancies Program at the University of California, San Diego, Moores Cancer Center. Dr. Kipps is a two-time awardee of a Specialized Center of Research (SCOR) in Leukemia grant from the Leukemia and Lymphoma Society, a two-time awardee of the NIH MERIT Award, and principal investigator of the CLL Research Consortium (CRC), which directed inter-institutional research among the leading investigators in CLL from across the country and abroad.
Dr. Kipps is the chair of the international workshop on CLL (iwCLL), and an awardee of the Rai/Binet medal for outstanding contributions to the field of leukemia research
08:45 - 09:45
Plenary Lectures - Session 1
Chairmen
Dr Guillermo Dighiero
(Uruguay)
[cv]
Dr Raúl Gabus
(Uruguay)
[cv]
Dr
Guillermo Dighiero
Uruguay
Curriculum Vitae:
URUGUAY
1960: Ingreso a la Facultad de Medicina. 1969: Graduación como médico. 1964: Practicante Interno del laboratorio Central del Hospital de Clínicas. 1968: Practicante Interno del Ministerio de Salud Pública. 1971: Asistente de la Clínica Semiológica de la Facultad de Medicina. 1975: Profesor Adjunto de la Clínica Semiológica de la Facultad de Medicina. 2004: Director Ejecutivo del Institut Pasteur de Montevideo.
FRANCIA
1975: Profesor Asociado de la Facultad de Medicina Paris VI. 1978: Docteur ès sciences. 1979: Ingreso al CNRS. 1984: Jefe de la Unidad de Inmuhematología e Inmunopatología del Instituto Pasteur. 1991: Director de Investigaciones de Primera Clase en el CNRS. 1996: Profesor del Instituto Pasteur. 1997: Director del Departamento de Fisiopatología del Instituto Pasteur. 1999: Presidente del Grupo Francés para el estudio de la Leucemia Linfoide Crónica
Curriculum Vitae:
Internal Medicine. Hematologist. President Organizing Committee - 5th LAG-CLL 2024, Uruguay.
Former Head of Department Hematology and BMT. Hospital Maciel. Montevideo. Uruguay.
Founding member of the Latin American Group on CLL.
Founding member in clinical and biology investigation in CLL. Hospital Maciel-Institut Pasteur. Montevideo.
Member of the IMC/ASH 2014.2022.
Founding member and Training Coordinator (LAVTP) in BMT for the Latin America Training Program /ASH 2014-2024
Speaker:
Dr
Thomas Kipps
(USA )
[cv]
Curriculum Vitae:
Is Distinguished Professor of Medicine, Evelyn and Edwin Tasch Chair in Cancer Research, Director of the Center for Novel Therapeutics, and Co-Director of the Hematologic Malignancies Program at the University of California, San Diego, Moores Cancer Center. Dr. Kipps is a two-time awardee of a Specialized Center of Research (SCOR) in Leukemia grant from the Leukemia and Lymphoma Society, a two-time awardee of the NIH MERIT Award, and principal investigator of the CLL Research Consortium (CRC), which directed inter-institutional research among the leading investigators in CLL from across the country and abroad.
Dr. Kipps is the chair of the international workshop on CLL (iwCLL), and an awardee of the Rai/Binet medal for outstanding contributions to the field of leukemia research
Speaker:
Dr
Nicholas Chiorazzi
(USA )
[cv]
Dr
Nicholas Chiorazzi
USA
Curriculum Vitae:
Is a physician-scientist who is Head of the Karches Center for Oncology Research in The Feinstein Institutes for Medical Research and is Professor of Molecular Medicine and of Medicine in the Zucker School of Medicine at Hofstra/Northwell. The research interests of the Chiorazzi team revolve around understanding the activation and maturation of B lymphocytes in health and disease, especially in patients with chronic lymphocytic leukemia (CLL). Over the years, the Chiorazzi team contributed impactful information about the immunobiology of CLL cells. The group’s collective works led to Dr. Chiorazzi receiving the Binet-Rai medal from the International Workshops on CLL.
09:45 - 10:15
Coffee break
10:15 - 11:15
Plenary Lectures - Session 2
Chairmen
Dr Eliana Abdelhay
(Brazil)
[cv]
Dr Gimena Dos Santos
(Uruguay)
[cv]
Dr Romina Gamberale
(Argentina)
[cv]
Dr
Eliana Abdelhay
Brazil
Curriculum Vitae:
Eliana Abdelhay, received her BSc in Physics at the Catholic University of Rio de Janeiro and her MSc and PhD at the Biophysics Institute at Federal University of Rio de Janeiro (UFRJ). She performed a postdoctoral training in Molecular Genetics at the Pasteur Institute, Paris, France. She was a teacher/researcher at UFRJ for 30 years and then moved to the Brazilian National Cancer Institute where she organized a Laboratory Division for Assistance and Research on neoplastic diseases. Actually, she is a Senior Researcher at the Brazilian National Cancer Institute (INCA), a Superior Researcher at CNPQ (Brazilian National Council of Scientific and Technical Research) and a Scientist of Rio de Janeiro State and leads the Stem Cell Laboratory at INCA. She authored more than 150 articles in peer- reviewed journals, gave more than 100 conferences in national and international meetings and formed 85 MSc and PhD students.
Dr
Gimena Dos Santos
Uruguay
Curriculum Vitae:
Internista. Hematóloga. Ex Asistente de la Cátedra de Hematología.
Magíster en Ciencias Médicas, candidata a PhD en el Institut Pasteur del Montevideo - Laboratorio de Leucemia Linfoide Crónica.
Hematóloga del Hospital Central de las Fuerzas Armadas y Seguro Americano.
Integrante del Grupo Uruguayo de Linfoma (GULi) y Grupo Uruguayo de LLC (CURU-LLC)
Dr
Romina Gamberale
Argentina
Curriculum Vitae:
Romina Gamberale, Ph.D., is currently Director of the Institute of Experimental Medicine (IMEX)-CONICET at the National Academy of Medicine in Buenos Aires, Argentina and Co-Director of the Laboratory of Onco-Immunology (https://imex.conicet.gov.ar/ ). She attended University of Buenos Aires where she majored in Cellular Biology in 1998 and received her Ph.D. in Cellular Biology in 2002 at the University of Buenos Aires studying the role of the microenvironment in Chronic Lymphocytic Leukemia (CLL) under the mentorship of Dr. Mirta Giordano. She obtained a fellowship of the French Society of Cancer to attend to Marie Curie Institute in Paris in 2001 to study the role of the tyrosine kinase Syk in dendritic cell maturation, under the supervision of Dr. Sebastian Amigorena. Then, in 2003 she obtained another research fellow to study the mutational status of CLL patients in the Pasteur Institute in Paris under the supervision of Dr. Guillermo Dighiero. She has been teaching Immunology at the School of Medicine at the University of Buenos Aires since 1998 and she is the co-Coordinator of the Immunology Course in the Hematologist Training Program of the Argentinian Society of Hematology since 2015. Her research group is interested in studying how the tumor microenvironment regulates the activation, proliferation and survival of CLL cells and their response to different therapeutic agents. Dr. Gamberale actively fosters the promotion of regional development of basic and clinical research in LLC. She participates in the Latin American Group of CLL (LAG-CLL) and also participates in the iwCLL Global Partnerships Subcommittee, a working subcommittee of international leaders in CLL whose objective is to improve the situation of CLL patients worldwide, promoting clinical and/or research training of hematologists/investigators, improving local research capacities, training of future academic leaders in CLL research, and CLL awareness among patients all over the world (https://www.iwcll.org/about/subcommittee/global-partnerships-subcommittee/).
Throughout his career, she has supervised the research of numerous undergraduate fellows, Ph.D students, post-docs and young investigators interested in CLL and publishes more than 50 papers in immunology and hematology international journals.
Speaker:
Dr
Jan Burger
(USA )
[cv]
Curriculum Vitae:
Is a Professor of Medicine at the MD Anderson Cancer Center in Houston, USA. Dr. Burger received his M.D./Ph.D. degree at Albert-Ludwigs-University in Freiburg, Germany, with subsequent clinical training and board certification in Internal Medicine and Hematology/Oncology at Freiburg University Hospital, before moving to MD Anderson in 2005. In 2006, Dr. Burger received the “Venia legendi” (Habilitation) for Internal Medicine at Albert-Ludwigs-University in Freiburg. Moreover, from 1996 to 1999, Dr. Burger received postdoctoral research training in Hematology and Immunology at the University of California, San Diego. As a clinical and laboratory investigator, Dr. Burger focuses on developing new therapeutic approaches for targeting the microenvironment in chronic lymphocytic leukemia (CLL), other B cell malignancies, and acute leukemias. Laboratory research by Dr. Burger’s group characterized B cell receptor (BCR)-associated kinases, such as BTK and PI3 kinases, as therapeutic targets. Dr. Burger serves as a principal investigator on clinical trials which explore these targets in CLL, and has been leading key trials that supported the approval of the BTK inhibitor ibrutinib (Resonate 2: ibrutinib for CLL frontline therapy). For his innovative research, Dr. Burger received several awards, among them, the Arthur Pappenheim Award by the DGHO, a Kimmel Scholar Award, ASCO Young Investigator and Career Development awards, the Leukemia and Lymphoma Society Scholar award, and the MD Anderson Faculty Scholar Award. Dr. Burger is a regular speaker at EHA and ASH, and has published in the leading Journals in his field.
Speaker:
Dr
Martina Seiffert
(Germany)
[cv]
Dr
Martina Seiffert
Germany
Curriculum Vitae:
Martina Seiffert is a group leader at the German Cancer Research Center in Heidelberg. She is interested in immune modulatory mechanisms in the tumor microenvironment, with a focus on chronic lymphocytic leukemia. Using innovative single-cell omics approaches and functional studies with primary cell culture and mouse models, her team deciphers mechanisms of immune suppression and T-cell dysfunction and develops novel immunotherapies.
11:15 - 12:30
Ongoing Biology Research in the region (1)
Chairmen
Dr Jan Burger
(USA )
[cv]
Dr Nicholas Chiorazzi
(USA )
[cv]
Dr Martina Seiffert
(Germany)
[cv]
Curriculum Vitae:
Is a Professor of Medicine at the MD Anderson Cancer Center in Houston, USA. Dr. Burger received his M.D./Ph.D. degree at Albert-Ludwigs-University in Freiburg, Germany, with subsequent clinical training and board certification in Internal Medicine and Hematology/Oncology at Freiburg University Hospital, before moving to MD Anderson in 2005. In 2006, Dr. Burger received the “Venia legendi” (Habilitation) for Internal Medicine at Albert-Ludwigs-University in Freiburg. Moreover, from 1996 to 1999, Dr. Burger received postdoctoral research training in Hematology and Immunology at the University of California, San Diego. As a clinical and laboratory investigator, Dr. Burger focuses on developing new therapeutic approaches for targeting the microenvironment in chronic lymphocytic leukemia (CLL), other B cell malignancies, and acute leukemias. Laboratory research by Dr. Burger’s group characterized B cell receptor (BCR)-associated kinases, such as BTK and PI3 kinases, as therapeutic targets. Dr. Burger serves as a principal investigator on clinical trials which explore these targets in CLL, and has been leading key trials that supported the approval of the BTK inhibitor ibrutinib (Resonate 2: ibrutinib for CLL frontline therapy). For his innovative research, Dr. Burger received several awards, among them, the Arthur Pappenheim Award by the DGHO, a Kimmel Scholar Award, ASCO Young Investigator and Career Development awards, the Leukemia and Lymphoma Society Scholar award, and the MD Anderson Faculty Scholar Award. Dr. Burger is a regular speaker at EHA and ASH, and has published in the leading Journals in his field.
Dr
Nicholas Chiorazzi
USA
Curriculum Vitae:
Is a physician-scientist who is Head of the Karches Center for Oncology Research in The Feinstein Institutes for Medical Research and is Professor of Molecular Medicine and of Medicine in the Zucker School of Medicine at Hofstra/Northwell. The research interests of the Chiorazzi team revolve around understanding the activation and maturation of B lymphocytes in health and disease, especially in patients with chronic lymphocytic leukemia (CLL). Over the years, the Chiorazzi team contributed impactful information about the immunobiology of CLL cells. The group’s collective works led to Dr. Chiorazzi receiving the Binet-Rai medal from the International Workshops on CLL.
Dr
Martina Seiffert
Germany
Curriculum Vitae:
Martina Seiffert is a group leader at the German Cancer Research Center in Heidelberg. She is interested in immune modulatory mechanisms in the tumor microenvironment, with a focus on chronic lymphocytic leukemia. Using innovative single-cell omics approaches and functional studies with primary cell culture and mouse models, her team deciphers mechanisms of immune suppression and T-cell dysfunction and develops novel immunotherapies.
Dra.
María Chiara Cassarino
(Argentina)
Dra.
María Cecilia Rodríguez Galán
(Argentina)
Dra.
Valeria Sarapura
(Argentina)
Dra.
Fernanda Azevedo
(Brazil)
Dr.
Diego Álvarez
(Chile)
Dra.
María Paula dos Santos
(Brazil)
12:30 - 12:45
Break
12:45 - 14:00
Symposium Beigene
Personalization of Therapy in CLL: New Paradigms
Chairmen:
Dr
Carolina Mahuad
(Argentina)
Speaker:
Dr
Raúl Cordoba Mascuñano
(Spain)
Speaker:
Dr
Carolina Mahuad
(Argentina)
Speaker:
Dr
Raúl Cordoba Mascuñano
(Spain)
Speaker:
Dr
Andrés Danielle
(Argentina)
Speaker:
Dr
Maximiliano Smietniasky
(Argentina)
14:00 - 15:30
Plenary Lectures - Session 3
Chairmen
Dr Juan Dupont
(Argentina)
[cv]
Dr Cecilia Guillermo
(Uruguay)
[cv]
Curriculum Vitae:
He has dedicated his medical career to onco-hematology. He became junior staff at Instituto de Investigaciones Hematològicas de Buenos Aires and was involved in acute leukemias and lymphomas. Part of international education was in Maryland Cancer Center, the Stanford University Cancer Center and the University Hospital in Seattle. He formed part of Grupo Argentino de Tratamiento de Leucemias Agudas (GATLA) and the Latin American Cancer Research Program (LACRIP). Since 1992, he became staff of CEMIC in Buenos Aires, where he also served as head of the Hematology, Bone Marrow Transplantation Unit and Transfusion Medicine Department (2015-22). He has been Vice (2019-21) and President (2021-23) of the Sociedad Argentina de Hematologìa. Indexed publications 24, published book chapters 4. Multiple national and international meeting abstracts. Teaching present activity: Hematology Specialist Career: Director, at IUC, Instituto Universitario CEMIC.
Dr
Cecilia Guillermo
Uruguay
Curriculum Vitae:
Is a specialist in Hematology, Clinical Pathology Laboratory and Bone Marrow Transplantation. She joined the University Hematology Department 34 years ago and has been instrumental in its inclusion in the GURU-CLL group and the development of the clinical aspects of CLL research in Uruguay.
Dr. Guillermo is a member of several professional societies, including ASH, EHA, and SHU. She is past president of the Uruguayan Society of Hematology (2015-2017).
She has published numerous articles in national and international journals.
Speaker:
Dr
Miguel Pavlovsky
(Argentina)
[cv]
Dr
Miguel Pavlovsky
Argentina
Curriculum Vitae:
Obtuvo su título de médico de la Universidad de Buenos Aires en al año 1990. Completó la residencia de Clínica Médica en el Hospital Privado de Comunidad de Mar del Plata en el año 1993. Realizo un fellow de Hematologia y trasplante en Fundaleu 1993-1994. Completó su especialización en Hematología y Oncología durante tres años en St. Elizabeth’s Medical Center (Universidad de Tufts) de la ciudad de Boston; USA del año 1994 al año 1997. Realizó entrenamiento en Trasplante de Médula Ósea en el Dana Farber Cancer Institute de Boston, Massachusetts durante 3 meses en al año 1996.
Realizo durante el año 2002 el Programa de Dirección de Empresas de Salud del Htal Austral (DIRES). Actualmente es Director Médico y Científico de FUNDALEU. Sus áreas de interés son LLC, Linfoma del Manto y Folicular, enfermedad de Waldenstrom, Linfoma Anaplasico y Mieloproliferativos, patologias en las que ha participado en numerosos ensayos clínicos como investigador principal (JUMP, HELIOS; SHINE; ACE-LY 308 y ACE-CL 311). Es miembro activo de la Sociedad Argentina de Hematología, American Society of Hematology (ASH), American Society of Clinical Oncology (ASCO) y European Society of Hematology (EHA).
Speaker:
Dr
Othman Al Sawaf
(Germany)
[cv]
Dr
Othman Al Sawaf
Germany
Curriculum Vitae:
Hematologist & Oncologist. Academic researcher from University of Cologne. Member of the German CLL study group. Principal investigator of phase I l and I l l trials. Key contributor to the CLLI 4 study
Speaker:
Dr
Francesc Bosch
(Spain)
[cv]
Curriculum Vitae:
Head of the Hematology Department at Vall d’Hebron University Hospital, Head of the Hematology Department at IOB Institute of Oncology, Professor at Universitat Autònoma de Barcelona, Spain- Francesc Bosch holds the position of Head of the Hematology Department at Vall d’Hebron University Hospital, as well as Head of the Hematology Department at IOB Institute of Oncology. Additionally, he serves as a Professor at the Universitat Autònoma de Barcelona. Dr. Bosch earned his medical degree from the University of Barcelona Medical School in 1988. In 1997, he was awarded a PhD by the University of Barcelona for his research on the over-expression of Cyclin D1 in chronic lymphoproliferative disorders. He completed a two-year postdoctoral stay at the laboratory of Professor Riccardo Dalla Favera at the Institute of Cancer Genetics, Columbia University, New York, USA. Subsequently, he continued his research in chronic lymphocytic leukemia (CLL) at Hospital Clinic, Barcelona, starting from 2000. In September 2009, Dr. Bosch assumed the role of Head of the Department of Hematology and Director of the Experimental Hematology Laboratory at Vall d’Hebron University Hospital in Barcelona. Renowned for his expertise in CLL, Dr. Bosch conducts both clinical and basic research, focusing on the molecular pathogenesis of CLL and the development of innovative therapeutic strategies. Presently, Dr. Bosch serves as the Chair of the Spanish CLL Working Group (GELLC), overseeing the development of clinical trials related to CLL in Spain. He has published more than 200 papers in peer-reviewed journals such as The New England Journal of Medicine, Nature Medicine, Cancer Cell, Blood, Journal of Clinical Oncology, and Leukemia. Additionally, he has authored or co-authored numerous reviews and book chapters on CLL and other lymphoproliferative disorders
15:30 - 16:00
Coffee break
16:00 - 17:00
Session
Clinical trials and tumor registries in LLC in 3 Latin American countries
Chairmen
Dr Celso Arrais
(Brazil)
[cv]
Dr Pablo Muxi
(Uruguay)
[cv]
Dr Ana Inés Landoni
(Uruguay)
[cv]
Curriculum Vitae:
Residency in Hematology and Hemotherapy at EPM/UNIFESP. PhD in Hematology from EPM/UNIFESP.
Postdoctoral fellowship at the University of Paris VII.
Currently Associate Professor and Head of the Hematology Department and Coordinator of the Bone Marrow Transplant Service at EPM/UNIFESP.
Coordinator of the Hematology and Bone Marrow Transplantation Service at Hospital Nove de Julho and National Director of Hematology at DASA.
Curriculum Vitae:
Name: Pablo Muxí
Academic training:
- Medical Doctor, specialist in Internal Medicine and Hematology
- Bachelor's Degree: Hematopoietic Stem Transplantation
Teaching Position:
Professor, Director of the British Hospital Hematology Postgraduate Course – CLAEH Faculty of Medicine
Assistance Charges:
Director of the Hematology and Hematopoietic SCT Unit, British Hospital. Uruguay
Others
Fulbright Scholar at Montefiore Medical Center Hospital in Bronx NYC 1993-1994.
National Grand Prize in Medicine – National Academy of Medicine. 2012
Scientific Committee World Congress of the International Society of Hematology 2007
Full Member of the National Academy of Medicine. 2013
Editorial Board: Journal of Clinical Oncology: 2013-2019
Dr
Ana Inés Landoni
Uruguay
Curriculum Vitae:
Doctor en Medicina, UDELAR Uruguay (Facultad de Medicina. Universidad de la República Oriental del Uruguay). Octubre, 1995. Especialista en Hematología, UDELAR Uruguay (Escuela de Graduados de la Facultad de Medicina de la Universidad de la República). Enero, 1999. Especialización en Trasplante de progenitores Hematopoyéticos, UDELAR Uruguay (Escuela de Graduados de la Facultad de Medicina de la Universidad de la República). Octubre, 2009. Maestría en Programa de Investigadores Biomedicos, PRO.IN.BIO.Uruguay (Escuela de Graduados de la Facultad de Medicina de la Universidad de la República) Junio 2010. Especialización en citometría de flujo clínico. UDELAR Uruguay (Escuela de Graduados de la Facultad de Medicina de la Universidad de la República). Octubre, 2023.
Dr
Miguel Pavlovsky
(Argentina)
[cv]
Dr
Miguel Pavlovsky
Argentina
Curriculum Vitae:
Obtuvo su título de médico de la Universidad de Buenos Aires en al año 1990. Completó la residencia de Clínica Médica en el Hospital Privado de Comunidad de Mar del Plata en el año 1993. Realizo un fellow de Hematologia y trasplante en Fundaleu 1993-1994. Completó su especialización en Hematología y Oncología durante tres años en St. Elizabeth’s Medical Center (Universidad de Tufts) de la ciudad de Boston; USA del año 1994 al año 1997. Realizó entrenamiento en Trasplante de Médula Ósea en el Dana Farber Cancer Institute de Boston, Massachusetts durante 3 meses en al año 1996.
Realizo durante el año 2002 el Programa de Dirección de Empresas de Salud del Htal Austral (DIRES). Actualmente es Director Médico y Científico de FUNDALEU. Sus áreas de interés son LLC, Linfoma del Manto y Folicular, enfermedad de Waldenstrom, Linfoma Anaplasico y Mieloproliferativos, patologias en las que ha participado en numerosos ensayos clínicos como investigador principal (JUMP, HELIOS; SHINE; ACE-LY 308 y ACE-CL 311). Es miembro activo de la Sociedad Argentina de Hematología, American Society of Hematology (ASH), American Society of Clinical Oncology (ASCO) y European Society of Hematology (EHA).
Dr
Nelson Hamerschlack
(Brazil)
[cv]
Dr
Nelson Hamerschlack
Brazil
Curriculum Vitae:
Possui graduação em Medicina pela Universidade Federal de São Paulo (Escola Paulista de Medicina) em 1978, especialização em Hematologia/Hemoterapia (1981), Clínica Médica (1990), Fellow da Cornell University Medical Center (1989/1990) e doutorado em Imunologia pela Universidade de São Paulo (1999).É Professor Livre-Docente junto ao Departamento de Pediatria (Disciplina de Pediatria Clínica) da Faculdade de Medicina da Universidade de São Paulo (2014). Atualmente é médico hematologista e hemoterapeuta do Hospital Israelita Albert Einstein, coordenador da Pós-Graduação em Hematologia/Hemoterapia e pesquisador afiliado do Instituo Israelita de Ensino e Pesquisa Albert Einstein.
Hematologista do Américas Oncologia. Membro do Conselho Científico da Associação Brasileira de Leucemias e Linfomas (ABRALE). Foi presidente da Sociedade Brasileira de Hematologia e Hemoterapa e do Centro de Hematologia de São Paulo, Diretor Clínico do Hospital Israelita Albert Einstein (1996-1999), Superintendente do Instituto Israelita Albert Einstein (2000-2003). Presidente da Sociedade Brasileira de Transplantes de Medula Óssea (2018-2021).Tem experiência na área de Medicina, atuando principalmente nos seguintes temas: anemias, agranulocitose, hemostasia e trombose, leucemias, linfomas, mieloma múltiplo, transplantes de medula óssea, doenças autoimunes e hemoterapia.
Dr
Mercedes Lassus
(Uruguay)
[cv]
Dr
Mercedes Lassus
Uruguay
Curriculum Vitae:
Medical graduate from UdelaR, Uruguay, oncology fellowship in the Mt Sinai hospital, New York City. Academic positions in Uruguay (Internal Medicine, University Hospital, Montevideo) and in the USA (National Cancer Institute, Bethesda, Md). Head of development in clinical oncology in two multinationals (Farmitalia Carlo Erba, Milan, Italy, and Ciba Geigy, Basel Switzerland). Independent consultant since 2000, coordinates the Uruguayan Group for the study of CLL (GURU-LLC) since 2018
17:00 - 17:30
Session
Tumor registries
Dr Celso Arrais
(Brazil)
[cv]
Dr Andres Addiego
(Uruguay)
[cv]
Curriculum Vitae:
Residency in Hematology and Hemotherapy at EPM/UNIFESP. PhD in Hematology from EPM/UNIFESP.
Postdoctoral fellowship at the University of Paris VII.
Currently Associate Professor and Head of the Hematology Department and Coordinator of the Bone Marrow Transplant Service at EPM/UNIFESP.
Coordinator of the Hematology and Bone Marrow Transplantation Service at Hospital Nove de Julho and National Director of Hematology at DASA.
Dr
Andres Addiego
Uruguay
Curriculum Vitae:
Hematólogo. Magister en Ciencias Médicas. Programa: Pro.In.Bio.
Monitor Científico. Sociedad Uruguaya de Hematología.
Asistente Departamento Básico de Medicina. Hospital de Clínicas. Facultad de Medicina, UDELAR.
Asistente Unidad Académica de Hematología. Hospital de Clínicas. Facultad de Medicina, UDELAR.
Auditorium 1
17:30 - 19:30
Poster session/Wine and Cheese evening
Co-chairs
Dr Jan Burger
(USA )
[cv]
Dr Carolina Oliver
(Uruguay)
[cv]
Dr Pablo Oppezzo
(Uruguay)
[cv]
Dr Martina Seiffert
(Germany)
[cv]
Curriculum Vitae:
Is a Professor of Medicine at the MD Anderson Cancer Center in Houston, USA. Dr. Burger received his M.D./Ph.D. degree at Albert-Ludwigs-University in Freiburg, Germany, with subsequent clinical training and board certification in Internal Medicine and Hematology/Oncology at Freiburg University Hospital, before moving to MD Anderson in 2005. In 2006, Dr. Burger received the “Venia legendi” (Habilitation) for Internal Medicine at Albert-Ludwigs-University in Freiburg. Moreover, from 1996 to 1999, Dr. Burger received postdoctoral research training in Hematology and Immunology at the University of California, San Diego. As a clinical and laboratory investigator, Dr. Burger focuses on developing new therapeutic approaches for targeting the microenvironment in chronic lymphocytic leukemia (CLL), other B cell malignancies, and acute leukemias. Laboratory research by Dr. Burger’s group characterized B cell receptor (BCR)-associated kinases, such as BTK and PI3 kinases, as therapeutic targets. Dr. Burger serves as a principal investigator on clinical trials which explore these targets in CLL, and has been leading key trials that supported the approval of the BTK inhibitor ibrutinib (Resonate 2: ibrutinib for CLL frontline therapy). For his innovative research, Dr. Burger received several awards, among them, the Arthur Pappenheim Award by the DGHO, a Kimmel Scholar Award, ASCO Young Investigator and Career Development awards, the Leukemia and Lymphoma Society Scholar award, and the MD Anderson Faculty Scholar Award. Dr. Burger is a regular speaker at EHA and ASH, and has published in the leading Journals in his field.
Dr
Carolina Oliver
Uruguay
Curriculum Vitae:
Médica hematóloga, diplomada en trasplante de MO.
Cargos: Hematóloga en Unidad de hematología y trasplante de MO del Hospital Británico.
Hematóloga en CASMU.
Miembro del Grupo Uruguayo de LLC, Grupo Uruguayo de Linfoma, GELL, ASH y EHA.
Curriculum Vitae:
Is a scientist with a strong focus on Immunology, Hematology, and Oncology.
He heads the Research Laboratory on Chronic Lymphocytic Leukemia (CLL) at the Pasteur Institute of Montevideo.
Dr. Oppezzo has participated in different national and international scientific committees in the field of CLL and coordinated the first project aimed at generating a CLL network in the region through the Ibero-American Program for Science and Technology for Development (CYTED).
He has published more than 60 articles, most of them focused on CLL prognosis and the role of the tumor microenvironment in the progression of B-cell malignancies
Dr
Martina Seiffert
Germany
Curriculum Vitae:
Martina Seiffert is a group leader at the German Cancer Research Center in Heidelberg. She is interested in immune modulatory mechanisms in the tumor microenvironment, with a focus on chronic lymphocytic leukemia. Using innovative single-cell omics approaches and functional studies with primary cell culture and mouse models, her team deciphers mechanisms of immune suppression and T-cell dysfunction and develops novel immunotherapies.
Reviewers
Dr Pablo Muxi
(Uruguay)
[cv]
Dr Florencia Palacios
(Uruguay)
[cv]
Dr Carolina Oliver
(Uruguay)
[cv]
Dr Pablo Oppezzo
(Uruguay)
[cv]
Dr Martina Seiffert
(Germany)
[cv]
Dr Fernando Bezares
(Argentina)
[cv]
Dr Jan Burger
(USA )
[cv]
Dr Romina Gamberale
(Argentina)
[cv]
Curriculum Vitae:
Name: Pablo Muxí
Academic training:
- Medical Doctor, specialist in Internal Medicine and Hematology
- Bachelor's Degree: Hematopoietic Stem Transplantation
Teaching Position:
Professor, Director of the British Hospital Hematology Postgraduate Course – CLAEH Faculty of Medicine
Assistance Charges:
Director of the Hematology and Hematopoietic SCT Unit, British Hospital. Uruguay
Others
Fulbright Scholar at Montefiore Medical Center Hospital in Bronx NYC 1993-1994.
National Grand Prize in Medicine – National Academy of Medicine. 2012
Scientific Committee World Congress of the International Society of Hematology 2007
Full Member of the National Academy of Medicine. 2013
Editorial Board: Journal of Clinical Oncology: 2013-2019
Dr
Florencia Palacios
Uruguay
Curriculum Vitae:
Dr. Palacios is an Assistant Professor at the Institut Pasteur Montevideo, Uruguay, specializing in cancer immunology. She completed her Ph.D. focusing on chronic lymphocytic leukemia (CLL) under the mentorship of Prof. Dighiero and Dr. Oppezzo at the Institut Pasteur Montevideo. Following her Ph.D., she pursued postdoctoral research with Prof. Chiorazzi, MD, and Prof. Rai, MD, at The Feinstein Institutes for Medical Research in the United States, where she investigated the intraclonal complexity of B cells and its impact on the progression of CLL. In 2021, Dr. Palacios returned to Uruguay as an Assistant Professor at the Institut Pasteur Montevideo. Her research interests lie in translational medicine, with a particular focus on discovering new therapeutic targets and treatments.
Dr
Carolina Oliver
Uruguay
Curriculum Vitae:
Médica hematóloga, diplomada en trasplante de MO.
Cargos: Hematóloga en Unidad de hematología y trasplante de MO del Hospital Británico.
Hematóloga en CASMU.
Miembro del Grupo Uruguayo de LLC, Grupo Uruguayo de Linfoma, GELL, ASH y EHA.
Curriculum Vitae:
Is a scientist with a strong focus on Immunology, Hematology, and Oncology.
He heads the Research Laboratory on Chronic Lymphocytic Leukemia (CLL) at the Pasteur Institute of Montevideo.
Dr. Oppezzo has participated in different national and international scientific committees in the field of CLL and coordinated the first project aimed at generating a CLL network in the region through the Ibero-American Program for Science and Technology for Development (CYTED).
He has published more than 60 articles, most of them focused on CLL prognosis and the role of the tumor microenvironment in the progression of B-cell malignancies
Dr
Martina Seiffert
Germany
Curriculum Vitae:
Martina Seiffert is a group leader at the German Cancer Research Center in Heidelberg. She is interested in immune modulatory mechanisms in the tumor microenvironment, with a focus on chronic lymphocytic leukemia. Using innovative single-cell omics approaches and functional studies with primary cell culture and mouse models, her team deciphers mechanisms of immune suppression and T-cell dysfunction and develops novel immunotherapies.
Dr
Fernando Bezares
Argentina
Curriculum Vitae:
Former Head of Hematology at the Hospital General de Agudos CABA "Teodoro Álvarez" until 2022 and former head of the Division Hematology at Policlínico Bancario (1996-2013).
Active member of GATLA from 1974 to 2023. Coordinator for Argentina of GRELIC (2009-2011). Member of CLL LAG and chairman of the IBAM 2018 held in Buenos Aires.
Has published more than 75 papers in national and international journals and is co-author of more than 150 papers presented at national and international conferences.
He participated in the publication of 6 books related to CLL, Chronic Lymphoproliferative Disorders, and Chronic T Cell Leukemias. He has been co-authoring of the Diagnostic and Treatment Guidelines of the Argentine Society of Hematology since 2009.
Curriculum Vitae:
Is a Professor of Medicine at the MD Anderson Cancer Center in Houston, USA. Dr. Burger received his M.D./Ph.D. degree at Albert-Ludwigs-University in Freiburg, Germany, with subsequent clinical training and board certification in Internal Medicine and Hematology/Oncology at Freiburg University Hospital, before moving to MD Anderson in 2005. In 2006, Dr. Burger received the “Venia legendi” (Habilitation) for Internal Medicine at Albert-Ludwigs-University in Freiburg. Moreover, from 1996 to 1999, Dr. Burger received postdoctoral research training in Hematology and Immunology at the University of California, San Diego. As a clinical and laboratory investigator, Dr. Burger focuses on developing new therapeutic approaches for targeting the microenvironment in chronic lymphocytic leukemia (CLL), other B cell malignancies, and acute leukemias. Laboratory research by Dr. Burger’s group characterized B cell receptor (BCR)-associated kinases, such as BTK and PI3 kinases, as therapeutic targets. Dr. Burger serves as a principal investigator on clinical trials which explore these targets in CLL, and has been leading key trials that supported the approval of the BTK inhibitor ibrutinib (Resonate 2: ibrutinib for CLL frontline therapy). For his innovative research, Dr. Burger received several awards, among them, the Arthur Pappenheim Award by the DGHO, a Kimmel Scholar Award, ASCO Young Investigator and Career Development awards, the Leukemia and Lymphoma Society Scholar award, and the MD Anderson Faculty Scholar Award. Dr. Burger is a regular speaker at EHA and ASH, and has published in the leading Journals in his field.
Dr
Romina Gamberale
Argentina
Curriculum Vitae:
Romina Gamberale, Ph.D., is currently Director of the Institute of Experimental Medicine (IMEX)-CONICET at the National Academy of Medicine in Buenos Aires, Argentina and Co-Director of the Laboratory of Onco-Immunology (https://imex.conicet.gov.ar/ ). She attended University of Buenos Aires where she majored in Cellular Biology in 1998 and received her Ph.D. in Cellular Biology in 2002 at the University of Buenos Aires studying the role of the microenvironment in Chronic Lymphocytic Leukemia (CLL) under the mentorship of Dr. Mirta Giordano. She obtained a fellowship of the French Society of Cancer to attend to Marie Curie Institute in Paris in 2001 to study the role of the tyrosine kinase Syk in dendritic cell maturation, under the supervision of Dr. Sebastian Amigorena. Then, in 2003 she obtained another research fellow to study the mutational status of CLL patients in the Pasteur Institute in Paris under the supervision of Dr. Guillermo Dighiero. She has been teaching Immunology at the School of Medicine at the University of Buenos Aires since 1998 and she is the co-Coordinator of the Immunology Course in the Hematologist Training Program of the Argentinian Society of Hematology since 2015. Her research group is interested in studying how the tumor microenvironment regulates the activation, proliferation and survival of CLL cells and their response to different therapeutic agents. Dr. Gamberale actively fosters the promotion of regional development of basic and clinical research in LLC. She participates in the Latin American Group of CLL (LAG-CLL) and also participates in the iwCLL Global Partnerships Subcommittee, a working subcommittee of international leaders in CLL whose objective is to improve the situation of CLL patients worldwide, promoting clinical and/or research training of hematologists/investigators, improving local research capacities, training of future academic leaders in CLL research, and CLL awareness among patients all over the world (https://www.iwcll.org/about/subcommittee/global-partnerships-subcommittee/).
Throughout his career, she has supervised the research of numerous undergraduate fellows, Ph.D students, post-docs and young investigators interested in CLL and publishes more than 50 papers in immunology and hematology international journals.
